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This medication may possibly include sugar and/or alcohol. Warning is suggested Should you have diabetes, Liquor dependence, or liver ailment. Talk to your medical professional or pharmacist about making use of this solution safely and securely.
The pharmacokinetics of Promethazine with Codeine Oral Alternative has not been characterized in people with renal impairment. Codeine pharmacokinetics can be altered in sufferers with renal failure. Clearance could be reduced and also the metabolites may perhaps accumulate to Substantially increased plasma levels in clients with renal failure when compared to people with typical renal functionality.
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If you believe There have been an overdose, contact your poison control Middle or get medical care immediately. Be able to convey to or show what was taken, the amount of, and when it took place. How do I keep and/or throw out Promethazine and Codeine?
Codeine: A review in rats and rabbits described no teratogenic outcome of codeine administered throughout the period of organogenesis in doses ranging from 5 to 120 mg/kg. Inside the rat, doses in the a hundred and twenty-mg/kg stage, from the poisonous selection with the Grownup animal, were being associated with a rise in embryo resorption at the time of implantation.
Affected person support programs (PAPs) are typically sponsored by check here pharmaceutical businesses and present Charge-totally free or discounted medicines, as well as copay programs, to people with very low get more info cash flow or those people who are uninsured/under-insured and satisfy particular requirements.
When presented concomitantly with promethazine, the dose of barbiturates should be diminished by a minimum of just one-half, and also the dose of narcotics should be reduced by one-quarter to read more at least one-50 %. Dosage need to be individualized. Extreme amounts of promethazine HCl relative to the narcotic may well lead to restlessness and motor hyperactivity in the individual with discomfort; these signs typically disappear with adequate Charge of the ache.
The outcome of promethazine and/or codeine to the later on growth and development with the newborn is not known.
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Administration of codeine could be accompanied by histamine launch and will be made use of with caution in atopic small children.
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The combination of promethazine hydrochloride and codeine phosphate is contraindicated here in pediatric sufferers less than 6 yrs of age. Concomitant administration of promethazine goods with other respiratory depressants has an Affiliation with respiratory despair, and at times Dying, in pediatric patients. The association does circuitously relate to individualized pounds-primarily based dosing, which might normally allow Secure administration.
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